CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Dietary phytophenols act as scavengers of reducing radicals
Shi, Yimin; Yao, Side(姚思德); Jia, Zhongjian; Lin, Nianyun(林念芸); Zheng, Rongliang
2011
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume124Issue:4Pages:1322
AbstractVerbascoside, pedicularioside A, cistanoside C, salidroside, 6-O-(E)-feruloyl-glucose and 6-O-(E)-p-hydroxycinnamoyl-glucose were isolated from Pedicularis species and other plants. The scavenging activities of these phytophenols towards hydrated electron, the strongest reducing radical, were investigated by pulse radiolysis. With the exception of salidroside, the other phytophenols react with hydrated electrons (e(aq)(-)) at rate constants close to the diffusion-controlled rate (4.9-7.5 x 10(9)M(-1) s(-1)), indicating that these phytophenols are effective e(aq)(-) scavengers. This property is consistent with the phytophenols' ability to quickly repair DNA radical anions. The comparison of the reaction rate constants indicates that the conjugated carbonyl group is essential to the e;(1 scavenging activities, whereas the phenolic hydroxyl groups, which determine the antioxidant capacity, have no significant effect on the e(aq)(-) scavenging activities. We propose that the reducing radical-scavenging activity of the phytophenols is a novel pharmacological mechanism for prevention and treatment of diseases in which reducing radicals play a key role. Our finding provides a criterion for screening the scavengers of reducing radicals. (C) 2010 Elsevier Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000284189400005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9488
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Shi, Yimin,Yao, Side,Jia, Zhongjian,et al. Dietary phytophenols act as scavengers of reducing radicals[J]. FOOD CHEMISTRY,2011,124(4):1322.
APA Shi, Yimin,Yao, Side,Jia, Zhongjian,Lin, Nianyun,&Zheng, Rongliang.(2011).Dietary phytophenols act as scavengers of reducing radicals.FOOD CHEMISTRY,124(4),1322.
MLA Shi, Yimin,et al."Dietary phytophenols act as scavengers of reducing radicals".FOOD CHEMISTRY 124.4(2011):1322.
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