CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations
Qi Wen-Peng(亓文鹏); Lei Xiao-Ling(雷晓玲)
2011
Source PublicationCHINESE PHYSICS LETTERS
ISSN0256-307X
Volume28Issue:4
AbstractInvestigating the interaction between protein and stretched DNA molecules has become a new way to study the protein DNA interaction. The conformations from different stretching methods give us a further understanding of the interaction between protein and DNA. We study the conformational variations of a 22-mer DNA caused by stretching both 3'- and 5'-termini by molecular dynamics simulations. It requires 250 kJ/mol to stretch the DNA molecule by 3'5'-termini for 3.5 nm and the force plateau is at 123.8 pN. The stretching 3'5'-termini leads to large values of the angle opening and the dihedral propeller between bases in one base pair, the double helix untwists from 34 degrees to 20 degrees and the successive base pairs rolls to the side of the DNA major groove. The distances between successive base pairs increases from 3.2 angstrom to 5.6 angstrom.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000289195200066
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9494
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Qi Wen-Peng,Lei Xiao-Ling. DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations[J]. CHINESE PHYSICS LETTERS,2011,28(4).
APA Qi Wen-Peng,&Lei Xiao-Ling.(2011).DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations.CHINESE PHYSICS LETTERS,28(4).
MLA Qi Wen-Peng,et al."DNA Conformational Variations Induced by Stretching 3 ' 5 '-Termini Studied by Molecular Dynamics Simulations".CHINESE PHYSICS LETTERS 28.4(2011).
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