CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface
Zhang, Yi(张益); Hu, Xiaofang; Sun, Jielin; Shen, Yi; Hu, Jun(胡钧); Xu, Xuemin; Shao, Zhifeng
2011
Source PublicationMICROSCOPY RESEARCH AND TECHNIQUE
ISSN1059-910X
Volume74Issue:7Pages:614
AbstractIn this mini-review we discuss our recent findings on imaging and manipulation of biological macromolecular structures by atomic force microscopy (AFM). In the first part of this review, we focus on high-resolution imaging of selected biological samples. AFM images of membrane proteins have revealed detailed conformational features related to identifiable biological functions. Different self-assembling behaviors of short peptides into supramolecular structures on various substrates under controlled environmental conditions have been systematically studied with AFM imaging. In the second part, we present a novel nano-manipulation technique for manipulating, isolating, amplifying, and sequencing of individual DNA molecules, which may find unique applications in the analysis of difficult sequence structures. Finally, we discuss how to characterize the elasticity of individual biomolecules and live cells. These results demonstrate that not only the high resolution capacity of the AFM is suited to resolve certain biological questions, but can also be applied to single molecule isolation and biomechanical analysis with its unique advantages. Microsc. Res. Tech. 74: 614-626, 2011. (C) 2010 Wiley-Liss, Inc.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000292570900006
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9519
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Zhang, Yi,Hu, Xiaofang,Sun, Jielin,et al. High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface[J]. MICROSCOPY RESEARCH AND TECHNIQUE,2011,74(7):614.
APA Zhang, Yi.,Hu, Xiaofang.,Sun, Jielin.,Shen, Yi.,Hu, Jun.,...&Shao, Zhifeng.(2011).High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface.MICROSCOPY RESEARCH AND TECHNIQUE,74(7),614.
MLA Zhang, Yi,et al."High-Resolution Imaging and Nano-Manipulation of Biological Structures on Surface".MICROSCOPY RESEARCH AND TECHNIQUE 74.7(2011):614.
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