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Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin
Zhang, Peng(张鹏); Li, Haixia(李海霞); Liu, Yancheng; Yao, Side(姚思德); Wang, Wenfeng(王文锋)
2011
Source PublicationZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
ISSN0942-9352
Volume225Issue:8Pages:843
AbstractThe photochemical properties of 4'-N-acetyl derivative of norfloxacin (ANFX) were investigated in different solutions. Both UV-Vis absorption and the quantum yields of excited states are pH-dependent, and pK(a) value of ground state for the protonation of 3-carboxylic group was determined to be 6.5 +/- 0.2. Pulse radiolysis and laser flash photolysis experiments were carried out to characterize transient species of ANFX and to investigate reactions with tryptophan (TrpH) and 2'-seoxyguanosine-5'-monophosphoric acid disodium salt (dGMP). The ANFX undergoes the photoejection of electron by a mixed mechanism of one-photon and two-photon processes. Under moderate laser energy conditions, two-photon process is predominantly. The ANFX radical dianion (ANFX(-H)(center dot 2-)) formed in reaction with e(aq)(-) is characterized by the absorption around 370 nm, and the rate constant was determined to be 1.2 x 10(10) dm(3) mol(-1) s(-1). The (3)ANFX(-H)(-*) is able to oxidize TrpH and dGMP with bimolecular rate constants of 5.4 x 10(8) and 9.5 x 10(6) dm(3) mol(-1) s(-1), respectively. The ANFX(-H)(center dot 2-) and the oxidized radicals of TrpH and dGMP were observed directly. Under aerobic conditions, the photo-oxidations involve both type 1 and type 11 mechanisms.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000294693000003
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9563
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Zhang, Peng,Li, Haixia,Liu, Yancheng,et al. Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin[J]. ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS,2011,225(8):843.
APA Zhang, Peng,Li, Haixia,Liu, Yancheng,Yao, Side,&Wang, Wenfeng.(2011).Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin.ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS,225(8),843.
MLA Zhang, Peng,et al."Photochemical Properties and Reactions with Biomolecules of 4 '-N-Acetyl Derivative of Norfloxacin".ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS 225.8(2011):843.
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