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Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives
Hata, Kuniki; Lin, Mingzhang; Katsumura, Yosuke; Muroya, Yusa; Fu, Haiying(付海英); Yamashita, Shinichi; Nakagawa, Hidehiko
2011
Source PublicationJOURNAL OF RADIATION RESEARCH
ISSN0449-3060
Volume52Issue:1Pages:15
AbstractA comparative study using the pulse radiolysis technique was carried out to investigate transient absorption spectra and rate constants for the reactions of (center dot)OH and N3(center dot) with edaravone (3-methyl-l-phenyl-2-pyrazolin-5-one) and its four analogue compounds, 1,3-dimethyl-2-pyrazolin-5-one, 3-methyl-1(pyridin-2-yl)-2-pyrazolin-5-one, 1-phenyl-3-trifluoromethyl-2-pyrazolin-5-one and 1-(4-chlorophenyl)-3methyl-2-pyrazolin-5-one. The results showed that, unlike reaction mechanisms previously proposed, the phenyl group of edaravone played an important role in the reaction with (center dot)OH and OH adducts to the phenyl group were formed. Quantum chemical calculations also strongly supported this attribution and suggested that the most favorable site for attacks by (center dot)OH is the anti position of the phenyl group. Moreover, the rate constants for the reactions of edaravone and its analogues towards (center dot)OH and N(3)(center dot) were about 8.0 x 10(9), and 4.0 x 10(9) dm(3) mol(-1) s(-1), respectively. Edaravone displayed higher reactivity compared to the others, in contrast to a previous report in which 3-methyl-1-(pyridin-2-yl)-2-pyrazolin-5-one showed the highest reactivity towards (center dot)OH.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000287335400003
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9569
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Hata, Kuniki,Lin, Mingzhang,Katsumura, Yosuke,et al. Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives[J]. JOURNAL OF RADIATION RESEARCH,2011,52(1):15.
APA Hata, Kuniki.,Lin, Mingzhang.,Katsumura, Yosuke.,Muroya, Yusa.,Fu, Haiying.,...&Nakagawa, Hidehiko.(2011).Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives.JOURNAL OF RADIATION RESEARCH,52(1),15.
MLA Hata, Kuniki,et al."Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives".JOURNAL OF RADIATION RESEARCH 52.1(2011):15.
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