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| Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate | |
| Xu, Xiaoping（许晓平）; Zhang, Yuanqing（张元庆）; Wang, Xudong（王旭东）; Guo, Xunxiang; Zhang, Xuezhu（张雪竹）; Qi, Yujin（漆玉金）; Shen, Yu-Mei（沈玉梅） | |
| 2011 | |
| Source Publication | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| ISSN | 0968-0896 |
| Volume | 19Issue:5Pages:1643 |
| Abstract | Partially acetylated generation five polyamidoamine (PAMAM) dendrimer (G5-Ac) was reacted with biotin and 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M-DTPA), respectively to form the complex Bt-G5-Ac-1B4M which was further conjugated with avidin to give the conjugate Av-G5-Ac-1B4M. Then both of the conjugates were radiolabeled with technetium-99m ((99m)Tc), respectively. Their in vitro cellular uptake study shows that the conjugate of Av-G5-Ac-1B4M-(99m)Tc exhibits much higher cellular uptake in HeLa cells than that of Bt-G5-Ac-1B4M-(99m)Tc. Accordingly the following evaluation such as in vitro/in vivo stability, biodistribution and micro-SPECT imaging was observed only for the conjugate of Av-G5-Ac-1B4M-(99m)Tc. (C) 2011 Elsevier Ltd. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000287740200007 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/9573 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Recommended Citation GB/T 7714 | Xu, Xiaoping,Zhang, Yuanqing,Wang, Xudong,et al. Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(5):1643. |
| APA | Xu, Xiaoping.,Zhang, Yuanqing.,Wang, Xudong.,Guo, Xunxiang.,Zhang, Xuezhu.,...&Shen, Yu-Mei.(2011).Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate.BIOORGANIC & MEDICINAL CHEMISTRY,19(5),1643. |
| MLA | Xu, Xiaoping,et al."Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate".BIOORGANIC & MEDICINAL CHEMISTRY 19.5(2011):1643. |
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