CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate
Xu, Xiaoping(许晓平); Zhang, Yuanqing(张元庆); Wang, Xudong(王旭东); Guo, Xunxiang; Zhang, Xuezhu(张雪竹); Qi, Yujin(漆玉金); Shen, Yu-Mei(沈玉梅)
2011
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
Volume19Issue:5Pages:1643
AbstractPartially acetylated generation five polyamidoamine (PAMAM) dendrimer (G5-Ac) was reacted with biotin and 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M-DTPA), respectively to form the complex Bt-G5-Ac-1B4M which was further conjugated with avidin to give the conjugate Av-G5-Ac-1B4M. Then both of the conjugates were radiolabeled with technetium-99m ((99m)Tc), respectively. Their in vitro cellular uptake study shows that the conjugate of Av-G5-Ac-1B4M-(99m)Tc exhibits much higher cellular uptake in HeLa cells than that of Bt-G5-Ac-1B4M-(99m)Tc. Accordingly the following evaluation such as in vitro/in vivo stability, biodistribution and micro-SPECT imaging was observed only for the conjugate of Av-G5-Ac-1B4M-(99m)Tc. (C) 2011 Elsevier Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000287740200007
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9573
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Xu, Xiaoping,Zhang, Yuanqing,Wang, Xudong,et al. Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(5):1643.
APA Xu, Xiaoping.,Zhang, Yuanqing.,Wang, Xudong.,Guo, Xunxiang.,Zhang, Xuezhu.,...&Shen, Yu-Mei.(2011).Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate.BIOORGANIC & MEDICINAL CHEMISTRY,19(5),1643.
MLA Xu, Xiaoping,et al."Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate".BIOORGANIC & MEDICINAL CHEMISTRY 19.5(2011):1643.
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