Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection | |
| He, Yao; Su, Shao; Xu, Tingting; Zhong, Yiling; Zapien, J. Antonio; Li, Jiang; Fan, Chunhai（樊春海）; Lee, Shuit-Tong | |
| 2011 | |
| Source Publication | NANO TODAY
 |
| ISSN | 1748-0132 |
| Volume | 6Issue:2Pages:122 |
| Abstract | A nanostructured complex, silicon nanowires (SiNWs) coated with in situ grown AgNPs (SiNWs@AgNPs), is developed as a well-defined surface-enhanced Raman Scattering (SERS)-active platform for ultrasensitive DNA detection. Such SiNWs@AgNPs nanostructure possesses an extremely high SERS enhancement factor of similar to 10(10). We design a DNA sensor based on the nanostructure via immobilization of capture probe DNA at the surface of AgNPs, and a sandwich strategy for the detection of target DNA that brings a reporter probe labeled with a dye to the proximity of the surface, leading to high SERS signals. This silicon nanostructure-based biosensor platform can detect a remarkably low DNA concentration at similar to 1 fM, which is comparable to the lowest DNA concentration ever detected via SERS. We expect this highly sensitive and robust SiNWs-based SERS platform may serve as a practical and powerful tool for biomolecular sensing and biomedical analysis. (C) 2011 Elsevier Ltd. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000290507200006 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/9587 |
| Collection | 中科院上海应用物理研究所2011-2019年 |
| Recommended Citation GB/T 7714 | He, Yao,Su, Shao,Xu, Tingting,et al. Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection[J]. NANO TODAY,2011,6(2):122. |
| APA | He, Yao.,Su, Shao.,Xu, Tingting.,Zhong, Yiling.,Zapien, J. Antonio.,...&Lee, Shuit-Tong.(2011).Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection.NANO TODAY,6(2),122. |
| MLA | He, Yao,et al."Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection".NANO TODAY 6.2(2011):122. |
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| Silicon nanowires-ba（763KB） | 开放获取 | -- | View Application Full Text | |||
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