CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection
He, Yao; Su, Shao; Xu, Tingting; Zhong, Yiling; Zapien, J. Antonio; Li, Jiang; Fan, Chunhai(樊春海); Lee, Shuit-Tong
2011
Source PublicationNANO TODAY
ISSN1748-0132
Volume6Issue:2Pages:122
AbstractA nanostructured complex, silicon nanowires (SiNWs) coated with in situ grown AgNPs (SiNWs@AgNPs), is developed as a well-defined surface-enhanced Raman Scattering (SERS)-active platform for ultrasensitive DNA detection. Such SiNWs@AgNPs nanostructure possesses an extremely high SERS enhancement factor of similar to 10(10). We design a DNA sensor based on the nanostructure via immobilization of capture probe DNA at the surface of AgNPs, and a sandwich strategy for the detection of target DNA that brings a reporter probe labeled with a dye to the proximity of the surface, leading to high SERS signals. This silicon nanostructure-based biosensor platform can detect a remarkably low DNA concentration at similar to 1 fM, which is comparable to the lowest DNA concentration ever detected via SERS. We expect this highly sensitive and robust SiNWs-based SERS platform may serve as a practical and powerful tool for biomolecular sensing and biomedical analysis. (C) 2011 Elsevier Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000290507200006
Citation statistics
Cited Times:190[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9587
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
He, Yao,Su, Shao,Xu, Tingting,et al. Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection[J]. NANO TODAY,2011,6(2):122.
APA He, Yao.,Su, Shao.,Xu, Tingting.,Zhong, Yiling.,Zapien, J. Antonio.,...&Lee, Shuit-Tong.(2011).Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection.NANO TODAY,6(2),122.
MLA He, Yao,et al."Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection".NANO TODAY 6.2(2011):122.
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