Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Synthesis of Novel Polyethylene Glycol (PEG)-Cyclofenil as Molecular Probe of Estrogen Receptor beta | |
| Yang Guang(杨光）; Zhu Hua（朱华）; Shen Yumei（沈玉梅） | |
| 2011 | |
| Source Publication | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| ISSN | 0253-2786 |
| Volume | 31Issue:5Pages:715 |
| Abstract | New polyethylene glycol (PEG)-cyclofenil analogues based on its good affinity to estrogen receptor beta, containing tridentate ligand chelating system, were synthesized as molecular probe precursors for single-photon emission computed tomography (SPECT) imaging of breast cancer. The precursors were radiolabeled with (99m)Tc successfully. The key step in the process was the preparation of PEG-substituted cyclofenil and the reaction was clear with high yield (98%) and rapid reaction rate (completed within 30 min). Each step of the whole process was performed with relatively high yield under mild conditions. The exploration is extremely valuable for the radiolabeled experiment and micro-SPECT imaging study. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000291508800017 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/9600 |
| Collection | 中科院上海应用物理研究所2011-2020年 |
| Recommended Citation GB/T 7714 | Yang Guang,Zhu Hua,Shen Yumei. Synthesis of Novel Polyethylene Glycol (PEG)-Cyclofenil as Molecular Probe of Estrogen Receptor beta[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,31(5):715. |
| APA | Yang Guang,Zhu Hua,&Shen Yumei.(2011).Synthesis of Novel Polyethylene Glycol (PEG)-Cyclofenil as Molecular Probe of Estrogen Receptor beta.CHINESE JOURNAL OF ORGANIC CHEMISTRY,31(5),715. |
| MLA | Yang Guang,et al."Synthesis of Novel Polyethylene Glycol (PEG)-Cyclofenil as Molecular Probe of Estrogen Receptor beta".CHINESE JOURNAL OF ORGANIC CHEMISTRY 31.5(2011):715. |
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