CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Ultra-photostable, non-cytotoxic, and highly fluorescent quantum nanospheres for long-term, high-specificity cell imaging
He, Yao; Lu, Haoting; Su, Yuanyuan; Sai, Liman; Hu, Mei; Fan, Chunhai(樊春海); Wang, Lianhui
2011
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume32Issue:8Pages:2133
AbstractA new class of fluorescent quantum nanospheres (QNs) is directly achieved in aqueous phase through a facile one-pot microwave irradiation (MWI) strategy. Multi-color QNs with maximum emission wavelengths ranging from 525 to 610 nm and PLQY of 30-60% are facilely prepared through this new MWI strategy. In addition to strong fluorescence, these QNs possess excellent photostability, preserving similar to 90% of the original intensity after 70 min high-power UV irradiation (100 W Xeon lamp). In sharp contrast, the fluorescence of CdTe/CdS/ZnS core-shell-shell quantum dots (QDs), recognized as established fluorescent probes with robust photostability, decrease to similar to 50% under the same conditions. Besides, cytotoxicity assessment demonstrates that the prepared QNs exhibit favorable cytocompatibility to K562 cells with high concentration (3 mu mol) and long-time incubation (24 h). Furthermore, cellular imaging results demonstrate that the as-prepared QNs are remarkably efficacious for long-term and high-specificity immunofluorescent cellular labeling, and multi-color cell imaging. Our systematical investigation clearly shows that these high-performance QNs may serve as practical and powerful tools for various biological researches, such as in vivo and in vitro imaging. (C) 2010 Elsevier Ltd. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000287061400014
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9610
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
He, Yao,Lu, Haoting,Su, Yuanyuan,et al. Ultra-photostable, non-cytotoxic, and highly fluorescent quantum nanospheres for long-term, high-specificity cell imaging[J]. BIOMATERIALS,2011,32(8):2133.
APA He, Yao.,Lu, Haoting.,Su, Yuanyuan.,Sai, Liman.,Hu, Mei.,...&Wang, Lianhui.(2011).Ultra-photostable, non-cytotoxic, and highly fluorescent quantum nanospheres for long-term, high-specificity cell imaging.BIOMATERIALS,32(8),2133.
MLA He, Yao,et al."Ultra-photostable, non-cytotoxic, and highly fluorescent quantum nanospheres for long-term, high-specificity cell imaging".BIOMATERIALS 32.8(2011):2133.
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