Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Enantioselective synthesis of no-carrier added (NCA) 6-[F-18]Fluoro-L-Dopa | |
| Yin, DZ(尹端沚）; Zhang, L（张岚）; Tang, GH; Tang, XL; Wang, YX（汪勇先） | |
| 2003 | |
| Conference Name | 4th International Conference on Isotopes |
| Source Publication | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY |
| Pages | 179 |
| Conference Date | MAR 10-14, 2002 |
| Conference Place | CAPE TOWN, SOUTH AFRICA |
| Abstract | 6-[F-18]Fluoro-L-Dopa (6-FDOPA) is the analogue of L-Dopa, the biosynthesis precursor for dopamine. As a PET tracer, it was widely applied for the presynaptic dopamine function studies in human brain. The application of a chiral phase-transfer-catalyst (PTC) in enantioselective synthesis of N.C.A. 6-[F-18]Fluoro-L-Dopa has been developed recently. An improved procedure was described in this study. The labeling precursor (6-Trimethylammoniumveratraldehyde Triflate) and PTC (O-Allyl-N-(9)-anthracenylcinchonidinium Bromide) were synthesized. A successful synthesis route was developed for the preparation of 6-[F-18]Fluoro-L-Dopa with high radiochemical yields (4-9%, decay uncorrected) and short synthesis time(80min). The radiochemical purity was over 99% and no D-isomer was detected by HPLC analysis using a chiral mobile phase. |
| ISSN | 0236-5731 |
| Indexed By | SCI |
| Funding Project | 应物所课题组 |
| Language | 英语 |
| Document Type | 会议论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/9802 |
| Collection | 中科院上海原子核所2003年前 |
| Recommended Citation GB/T 7714 | Yin, DZ,Zhang, L,Tang, GH,et al. Enantioselective synthesis of no-carrier added (NCA) 6-[F-18]Fluoro-L-Dopa[C],2003:179. |
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