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Enantioselective synthesis of no-carrier added (NCA) 6-[F-18]Fluoro-L-Dopa
Yin, DZ(尹端沚); Zhang, L(张岚); Tang, GH; Tang, XL; Wang, YX(汪勇先)
2003
Conference Name4th International Conference on Isotopes
Source PublicationJOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
Pages179
Conference DateMAR 10-14, 2002
Conference PlaceCAPE TOWN, SOUTH AFRICA
Abstract6-[F-18]Fluoro-L-Dopa (6-FDOPA) is the analogue of L-Dopa, the biosynthesis precursor for dopamine. As a PET tracer, it was widely applied for the presynaptic dopamine function studies in human brain. The application of a chiral phase-transfer-catalyst (PTC) in enantioselective synthesis of N.C.A. 6-[F-18]Fluoro-L-Dopa has been developed recently. An improved procedure was described in this study. The labeling precursor (6-Trimethylammoniumveratraldehyde Triflate) and PTC (O-Allyl-N-(9)-anthracenylcinchonidinium Bromide) were synthesized. A successful synthesis route was developed for the preparation of 6-[F-18]Fluoro-L-Dopa with high radiochemical yields (4-9%, decay uncorrected) and short synthesis time(80min). The radiochemical purity was over 99% and no D-isomer was detected by HPLC analysis using a chiral mobile phase.
ISSN0236-5731
Indexed BySCI
Funding Project应物所课题组
Language英语
Document Type会议论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9802
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Yin, DZ,Zhang, L,Tang, GH,et al. Enantioselective synthesis of no-carrier added (NCA) 6-[F-18]Fluoro-L-Dopa[C],2003:179.
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