CAS OpenIR  > 中科院上海原子核所2003年前
[Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection
Yu, JF(于俊锋); Yin, DZ(尹端沚); Min, XF; Guo, ZL; Zhang, J; Wang, YX; Knapp, FF
1999
Source PublicationNUCLEAR MEDICINE AND BIOLOGY
ISSN0969-8051
Volume26Issue:5Pages:573
AbstractIntralesional therapy has been shown to be an effective treatment for tumors. In this study, the suitability of [Re-188]rhenium sulfide suspension for tumor treatment following intra-tumor injection was evaluated. The [Re-188]rhenium sulfide suspension was radiolabeled with Re-188 with a radiochemical yield of more than 96%. In vitro stability studies revealed that more than 99% of the Re-188 remained in sulfide form over a 3-day period. After ultrasonication for 5 or 10 min, the main particle size was 1-5 mu m. Two [Re-188]rhenium sulfide suspensions ultrasonicated for 5 and 10 min, respectively, were injected into separate group of tumor-bearing mice that were killed after specified times to compare the retention of Re-188 in tumors and the leakage to different organs by periods and organs removed to gamma counting. The mean retention percentages of Re-188 in tumors injected with suspension ultrasonicated for 5 (or 10) min were as follows: 1 h, 90.5 +/- 7.7% (83.1 +/- 13.7%); 24 h, 92.2 +/- 8.6% (83.9 +/- 9.8%); 48 h, 88.3 +/- 10.9% (80.2 +/- 3.8%); and 72 h, 91.5 +/- 7.6% (78.8 +/- 3.0%). Tumor-inhibiting ratio was 96.5%. These results demonstrated that [Re-188]rhenium sulfide suspension is an effective radiopharmaceutical for tumor treatment by intralesional therapy. (C) 1999 Elsevier Science Inc. All rights reserved.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000081586800012
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9841
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Yu, JF,Yin, DZ,Min, XF,et al. [Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection[J]. NUCLEAR MEDICINE AND BIOLOGY,1999,26(5):573.
APA Yu, JF.,Yin, DZ.,Min, XF.,Guo, ZL.,Zhang, J.,...&Knapp, FF.(1999).[Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection.NUCLEAR MEDICINE AND BIOLOGY,26(5),573.
MLA Yu, JF,et al."[Re-188]rhenium sulfide suspension: A potential radiopharmaceutical for tumor treatment following intra-tumor injection".NUCLEAR MEDICINE AND BIOLOGY 26.5(1999):573.
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