CAS OpenIR  > 中科院上海原子核所2003年前
An improved radiochemical synthesis of N-succinimidyl 4-F-18-(fluoromethyl)benzoate and the labeling of IgG
Li, JL; Wang, YX(汪勇先); Tian, HB; Zhou, W(周伟); Zhang, XL; Lin, YW; Yin, DZ(尹端沚)
2002
Source PublicationJOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
ISSN0236-5731
Volume254Issue:2Pages:415
AbstractN-succinimidyl 4-F-18-(fluoromethyl)benzoate ((SFMB)-F-18) for labeling proteins has been synthesized. Factors affecting the radiochemical synthesis of (SFMB)-F-18 such as reaction solvents temperature, the mole ratio of K2.2.2. to K2CO3 and reaction time were studied. The best labeling conditions were as follows: dry acetonitrile as solvent, a mole ratio of K2.2.2 to K2CO3 of 1:1, and a reaction time of 5 minutes at 80 degreesC. The radiochemical yield was about 57% (EOS), over 3 times that published. IgG was indirectly labeled by (SFMB)-F-18 and the labeling conditions were studied. The optimal conditions were: pH 7.8-8.5, reaction time: 15 minutes, yield was above 80% (corrected by decay).
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000179305000036
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9861
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Li, JL,Wang, YX,Tian, HB,et al. An improved radiochemical synthesis of N-succinimidyl 4-F-18-(fluoromethyl)benzoate and the labeling of IgG[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2002,254(2):415.
APA Li, JL.,Wang, YX.,Tian, HB.,Zhou, W.,Zhang, XL.,...&Yin, DZ.(2002).An improved radiochemical synthesis of N-succinimidyl 4-F-18-(fluoromethyl)benzoate and the labeling of IgG.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,254(2),415.
MLA Li, JL,et al."An improved radiochemical synthesis of N-succinimidyl 4-F-18-(fluoromethyl)benzoate and the labeling of IgG".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 254.2(2002):415.
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