CAS OpenIR  > 中科院上海原子核所2003年前
Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)
Li, QN(李晴暖); Xiu, Y; Zhang, XD(张晓东); Liu, RL(刘瑞丽); Du, QQ; Sun, AG; Chen, SL; Li, WX(李文新)
AbstractThe biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand the biodistribution of C-60 derivatives as drugs or drug carriers, a simple water-soluble derivative C-60(OH)(x)(O)(y) was labeled with Te-99m. A gamma -counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow from all tissues except for brain. The compound might be excreted through urine and enteron. The biodistribution shows some difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study is needed to rind out to what extent the C60 itself determines the biodistribution of derivatives.
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Funding Project应物所项目组
WOS IDWOS:000172324000010
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GB/T 7714
Li, QN,Xiu, Y,Zhang, XD,et al. Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)[J]. CHINESE SCIENCE BULLETIN,2001,46(19):1615.
APA Li, QN.,Xiu, Y.,Zhang, XD.,Liu, RL.,Du, QQ.,...&Li, WX.(2001).Biodistribution of fullerene derivative C-60(OH)(x)(O)(y).CHINESE SCIENCE BULLETIN,46(19),1615.
MLA Li, QN,et al."Biodistribution of fullerene derivative C-60(OH)(x)(O)(y)".CHINESE SCIENCE BULLETIN 46.19(2001):1615.
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