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DISTRIBUTION OF BROMO[METHYLENE-H-3]ACETAMIDE IN ONCOMELANIA SNAILS, CARPS, AND MICE
WANG, GF; SONG, GM; WANG, GP(王国平); ZHOU, MY(周美英); ZHAO, XL(赵夏令); BECKER, W
1991
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN0253-9756
Volume12Issue:3Pages:232
AbstractBromoacetamide show a high molluscicidal effect, low toxicity to fish and good solubility in water. It is a promising molluscicide. The present paper reported the distribution of bromo[methylene-H-3]acetamide in Oncomelania snails, carps, and mice. Radioactivity in animals was measured by liquid scintillation counting. In Oncomelania snails the radioactivity gradually increased with exposure time and drug concentration. The highest level was found in the head-foot, reaching 12.5 x 10(3) dpm . mg-1 after exposure to the drug for 24 h, whereas the levels in liver and other tissue were 3.0 x 10(3) and 3.8 x 10(3) dpm . mg-1 respectively. Carps absorbed bromo[methylene-H-3]acetamide similarly as in Oncomelania snails, but the levels in tissues were less than those in Oncomelania snails. Bromo[methylene-H-3]acetamide 0.5 ml (1.4-mu-mol . L-1) was given ig to mice. Blood samples of 3 mice were collected at 0.5, 1, 3, 6, 12, 24 and 96 h after ig. The peak levels was found within 12 h and then declined gradually.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:A1991FL66500011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9942
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
WANG, GF,SONG, GM,WANG, GP,et al. DISTRIBUTION OF BROMO[METHYLENE-H-3]ACETAMIDE IN ONCOMELANIA SNAILS, CARPS, AND MICE[J]. ACTA PHARMACOLOGICA SINICA,1991,12(3):232.
APA WANG, GF,SONG, GM,WANG, GP,ZHOU, MY,ZHAO, XL,&BECKER, W.(1991).DISTRIBUTION OF BROMO[METHYLENE-H-3]ACETAMIDE IN ONCOMELANIA SNAILS, CARPS, AND MICE.ACTA PHARMACOLOGICA SINICA,12(3),232.
MLA WANG, GF,et al."DISTRIBUTION OF BROMO[METHYLENE-H-3]ACETAMIDE IN ONCOMELANIA SNAILS, CARPS, AND MICE".ACTA PHARMACOLOGICA SINICA 12.3(1991):232.
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