Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA | |
| Zhang, L（张岚）; Tang, GH; Yin, DZ（尹端沚）; Tang, XL; Wang, YX（汪勇先） | |
| 2002 | |
| Source Publication | APPLIED RADIATION AND ISOTOPES
 |
| ISSN | 0969-8043 |
| Volume | 57Issue:2Pages:145 |
| Abstract | The application of a chiral phase-transfer-catalyst (PTC) in the synthesis of N.C.A. 6-[F-18]fluoro-L-DOPA has been recently developed. The 6-trimethylammoniumveratraldehyde triflate precursor and PTC (O-allyl-N-(9)-anthracenyl-cinchorridinium bromide) were synthesized and successful synthesis route was developed for the preparation of 6-[F-18]fluoro-L-DOPA with high radiochemical yields (4-9%, decay uncorrected) and short synthesis time (80 min). The radiochemical purity was over 99% and no D-isomer was detected by HPLC analysis using a chiral mobile phase. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000176423600002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/9959 |
| Collection | 中科院上海原子核所2003年前 |
| Recommended Citation GB/T 7714 | Zhang, L,Tang, GH,Yin, DZ,et al. Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA[J]. APPLIED RADIATION AND ISOTOPES,2002,57(2):145. |
| APA | Zhang, L,Tang, GH,Yin, DZ,Tang, XL,&Wang, YX.(2002).Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA.APPLIED RADIATION AND ISOTOPES,57(2),145. |
| MLA | Zhang, L,et al."Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA".APPLIED RADIATION AND ISOTOPES 57.2(2002):145. |
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