CAS OpenIR  > 中科院上海原子核所2003年前
Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA
Zhang, L(张岚); Tang, GH; Yin, DZ(尹端沚); Tang, XL; Wang, YX(汪勇先)
AbstractThe application of a chiral phase-transfer-catalyst (PTC) in the synthesis of N.C.A. 6-[F-18]fluoro-L-DOPA has been recently developed. The 6-trimethylammoniumveratraldehyde triflate precursor and PTC (O-allyl-N-(9)-anthracenyl-cinchorridinium bromide) were synthesized and successful synthesis route was developed for the preparation of 6-[F-18]fluoro-L-DOPA with high radiochemical yields (4-9%, decay uncorrected) and short synthesis time (80 min). The radiochemical purity was over 99% and no D-isomer was detected by HPLC analysis using a chiral mobile phase. (C) 2002 Elsevier Science Ltd. All rights reserved.
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Funding Project应物所项目组
WOS IDWOS:000176423600002
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Document Type期刊论文
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GB/T 7714
Zhang, L,Tang, GH,Yin, DZ,et al. Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA[J]. APPLIED RADIATION AND ISOTOPES,2002,57(2):145.
APA Zhang, L,Tang, GH,Yin, DZ,Tang, XL,&Wang, YX.(2002).Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA.APPLIED RADIATION AND ISOTOPES,57(2),145.
MLA Zhang, L,et al."Enantioelective synthesis of no-carrier-added (NCA) 6-[F-18]fluoro-L-DOPA".APPLIED RADIATION AND ISOTOPES 57.2(2002):145.
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