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EXAFS study on the local atomic structures around iron in glycosylated haemoglobin
Wu, ZH; Benfield, RE; Wang, YS(王荫松); Guo, L; Tan, MG(谈明光); Zhang, HD; Ge, YX; Grandjean, D
2001
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY
ISSN0031-9155
Volume46Issue:3Pages:N71
AbstractSamples with 5.1%, 9.8% and 15.3% HbA1c were extracted from normal subjects and patients with slight and serious diabetes respectively. Extended x-ray absorption fine structure spectra of Fe K absorption were collected at the EXAFS experimental station of the Beijing Synchrotron Radiation Facility. The step-by-step fluorescent mode was employed with a count time of 10 s per point. Several independent scans were averaged to eliminate the statistical noise. Reference backscattering amplitudes and phaseshifts were calculated using the curve wave theory (FEFF code) of EXAFS. Apart from the nitrogen neighbours around the central iron atom, oxygen neighbours are also found. The Fe-N bond length increases by about 0.02 Angstrom for the sample with 15.3% HbA1c compared with the others, but the Fe-O bond length is almost unchanged. With increasing of HbA1c concentration, the content of Hb increases and the content of HbO(2) decreases. This demonstrates that the glycosylation of haemoglobin will decrease its ability to carry oxygen.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000167520400024
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9966
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Wu, ZH,Benfield, RE,Wang, YS,et al. EXAFS study on the local atomic structures around iron in glycosylated haemoglobin[J]. PHYSICS IN MEDICINE AND BIOLOGY,2001,46(3):N71.
APA Wu, ZH.,Benfield, RE.,Wang, YS.,Guo, L.,Tan, MG.,...&Grandjean, D.(2001).EXAFS study on the local atomic structures around iron in glycosylated haemoglobin.PHYSICS IN MEDICINE AND BIOLOGY,46(3),N71.
MLA Wu, ZH,et al."EXAFS study on the local atomic structures around iron in glycosylated haemoglobin".PHYSICS IN MEDICINE AND BIOLOGY 46.3(2001):N71.
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