CAS OpenIR  > 中科院上海原子核所2003年前
Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl
Li, YM; Han, ZH(韩正辉); Jiang, SH; Jiang, Y; Yao, SD; Zhu, DY
2000
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN0253-9756
Volume21Issue:12Pages:1125
AbstractAIM: To investigate the antioxidative activity of the constituents of the roots of Scrophularia ningpoensis (Chinese name: Xuanshen). MEHTODS: The main compounds from the roots of Scrophularia ningpoensis were isolated and identified by chromatography and FABMS, NMR etc. Using the techniques of pulse radiolysis, the electron transfers from iridoid glycosides (IG) or phenylpropanoid glycosides (PG) to oxidized OH radical adducts of 2'-deoxyadenosine-5'-monophosphate acid (dAMP) or 2'-deoxyguanosine-5'-monophosphate acid (dGMP) were observed. RESULTS: Two IG: harpagoside and harpagide, two PG: angoroside C and acteoside were obtained as the main hydrophilic constituents of the plant. At 0.1 mmol/L concentration, angoroside C and acteoside were able to repair the oxidized OH adducts dAMP and dGMP significantly. However, harpagoside and harpagide had no such effect. The electron transfer rate constants of angoroside C with dAMP and dGMP were 4.2 x 10(8) and 10.3 x 10(8) L . mol(-1) . s(-1); the electron transfer rate constants of acteoside with dAMP and dGMP were 5.3 x 10(8) and 20.2 x 10(8) L. mol(-1) . s(-1). CONCLUSION: PG from Scrophularia ningpoensis have a potent antioxidative activity for reducting of the oxidized OH adducts of dAMP and dGMP.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000165828500011
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9974
Collection中科院上海原子核所2003年前
Recommended Citation
GB/T 7714
Li, YM,Han, ZH,Jiang, SH,et al. Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl[J]. ACTA PHARMACOLOGICA SINICA,2000,21(12):1125.
APA Li, YM,Han, ZH,Jiang, SH,Jiang, Y,Yao, SD,&Zhu, DY.(2000).Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl.ACTA PHARMACOLOGICA SINICA,21(12),1125.
MLA Li, YM,et al."Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl".ACTA PHARMACOLOGICA SINICA 21.12(2000):1125.
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