CAS OpenIR

Browse/Search Results:  1-10 of 19 Help

Selected(0)Clear Items/Page:    Sort:
Discovery of a novel small inhibitor RJ19 targeting to human Hsp90 期刊论文
NUCLEAR SCIENCE AND TECHNIQUES, 2017, 卷号: 28, 期号: 10, 页码: -
Authors:  Cao, HL;  Lyu, KK;  Liu, B;  Li, J;  He, JH
Adobe PDF(1346Kb)  |  Favorite  |  View/Download:100/16  |  Submit date:2018/08/30
Shock-protein 90  Atp Hydrolysis  Chaperone  Identification  Binding  Design  Agent  
CHIP involves in non-small cell lung cancer prognosis through VEGF pathway 期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2016, 卷号: 83, 页码: 271-276
Authors:  Qian, TT;  Wang, J;  Wang, QF;  Liu, YC;  Yu, SJ;  Wang, ZQ;  Sun, DM;  Wang, SL;  Qian, TT (reprint author), Tongji Univ, Sch Life Sci & Technol, 1239 Siping Rd, Shanghai 200092, Peoples R China.
Adobe PDF(988Kb)  |  Favorite  |  View/Download:119/28  |  Submit date:2017/03/02
Nsclc  Chip  Vegf-vegfr2  Prognosis  
The Sinocyclocheilus cavefish genome provides insights into cave adaptation 期刊论文
BMC BIOLOGY, 2016, 卷号: 14, 期号: -, 页码: —
Authors:  Yang, JX;  Chen, XL;  Bai, J;  Fang, DM;  Qiu, Y;  Jiang, WS;  Yuan, H;  Bian, C;  Lu, J;  He, SY;  Pan, XF;  Zhang, YL;  Wang, XA;  You, XX;  Wang, YS;  Sun, Y;  Mao, DQ;  Liu, Y;  Fan, GY;  Zhang, H;  Chen, XY;  Zhang, XH;  Zheng, LP;  Wang, JT;  Cheng, L;  Chen, JM;  Ruan, ZQ;  Li, J;  Yu, H;  Peng, C;  Ma, XY;  Xu, JM;  He, Y;  Xu, ZF;  Xu, P;  Wang, J;  Yang, HM;  Wang, J;  Whitten, T;  Xu, X;  Shi, Q;  Yang, JX (reprint author), Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China.
Adobe PDF(3684Kb)  |  Favorite  |  View/Download:203/43  |  Submit date:2016/09/12
Maximum-likelihood Phylogenies  Gene Family Evolution  Molecular Phylogeny  Blind Cavefish  Oculocutaneous Albinism  Epidermolysis-bullosa  Stripe Formation  Tibetan Plateau  Candidate Genes  Dna-sequences  
Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 卷号: 13, 期号: 5, 页码: 1531—1535
Authors:  Ren, J;  Yang, M;  Liu, HC;  Cao, DY;  Chen, DQ;  Li, J;  Tang, L;  He, JH;  Chen, YL;  Geng, MY;  Xiong, B;  Shen, JK
Adobe PDF(1731Kb)  |  Favorite  |  View/Download:115/41  |  Submit date:2015/12/09
Heat-shock Proteins  3-component Condensation  Discovery  Heat-shock-protein-90  Identification  Pyrazines  Potent  Chaperone  
Selenite-Induced Toxicity in Cancer Cells Is Mediated by Metabolic Generation of Endogenous Selenium Nanoparticles 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2015, 卷号: 14, 期号: 2, 页码: 1127—1136
Authors:  Bao, P;  Chen, Z;  Tai, RZ;  Shen, HM;  Martin, FL;  Zhu, YG
Adobe PDF(9132Kb)  |  Favorite  |  View/Download:101/20  |  Submit date:2015/12/09
Sodium-selenite  Mitochondrial Damage  Oxidative Stress  Hepg2 Cells  Apoptosis  Cytotoxicity  Thioredoxin  Attenuation  Glycolysis  Expression  
基于碎片方法的N-异噁唑-5-酰胺类HSP90抑制剂的发现 会议论文
第十二届全国青年药学工作者最新科研成果交流会论文集, 中国江苏南京
Authors:  陈丹琦;  沈爱军;  李健;  石峰;  Wuyan Chen;  任景;  黄敏;  刘红椿;  许叶春;  王昕;  陈奕;  杨敏;  何建华;  王月琴;  王丽萍;  耿美玉;  熊兵;  沈竞康
View  |  Adobe PDF(175Kb)  |  Favorite  |  View/Download:370/105  |  Submit date:2015/03/13
Hsp90  抑制剂  基于碎片的药物发现  晶体学  
Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality 期刊论文
SCIENTIFIC REPORTS, 2014, 卷号: 4
Authors:  Guo, YZ;  Sun, LH;  Oberthuer, D;  Zhang, CY;  Shi, JY;  Di, JL;  Zhang, BL;  Cao, HL;  Liu, YM;  Li, J;  Wang, Q;  Huang, HH;  Liu, J;  Schulz, JM;  Zhang, QY;  Zhao, JL;  Betzel, C;  He, JH;  Yin, DC;  Christian.Betzel@uni-hamburg.de;  hejianhua@sinap.ac.cn;  yindc@nwpu.edu.cn
View  |  Adobe PDF(2657Kb)  |  Favorite  |  View/Download:256/75  |  Submit date:2015/03/13
Dynamic Light-scattering  Heterogeneous Nucleation  Separating Nucleation  Structural Genomics  Lysozyme  Surfaces  Optimization  Orientation  Nucleants  Growth  
Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 11, 页码: 2525—2529
Authors:  Ren, J;  Li, J;  Wang, YQ;  Chen, WY;  Shen, AJ;  Liu, HC;  Chen, DQ;  Cao, DY;  Li, YL;  Zhang, NX;  Xu, YC;  Geng, MY;  He, JH;  Xiong, B;  Shen, JK;  mygeng@simm.ac.cn;  hejh@sinap.ac.cn;  bxiong@simm.ac.cn
View  |  Adobe PDF(2396Kb)  |  Favorite  |  View/Download:177/50  |  Submit date:2015/03/13
Shock-protein 90  Drug Discovery  Chaperone  Ligand  Heat-shock-protein-90  Design  
Hsp90N-抑制剂复合物晶体结构解析及火球菌RecJ蛋白初步晶体学研究 学位论文
: 中国科学院研究生院, 2013
Authors:  杨敏
Adobe PDF(3276Kb)  |  Favorite  |  View/Download:218/0  |  Submit date:2013/12/06
人源hsp90n抑制剂  结构解析  火球菌recj蛋白  晶体衍射  
人源GDP-岩藻糖合成酶结构解析与火球菌8-氧鸟嘌呤DNA糖苷酶功能研究 学位论文
: 中国科学院研究生院, 2013
Authors:  周欢
Adobe PDF(7315Kb)  |  Favorite  |  View/Download:322/0  |  Submit date:2013/12/06
Gdp-岩藻糖  Fx  Gdp-岩藻糖合成酶  火球菌  8-氧鸟嘌呤dna糖苷酶