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Discovery of a novel small inhibitor RJ19 targeting to human Hsp90 期刊论文
NUCLEAR SCIENCE AND TECHNIQUES, 2017, 卷号: 28, 期号: 10, 页码: -
Authors:  Cao, HL;  Lyu, KK;  Liu, B;  Li, J;  He, JH
View  |  Adobe PDF(1346Kb)  |  Favorite  |  View/Download:102/17  |  Submit date:2018/08/30
Shock-protein 90  Atp Hydrolysis  Chaperone  Identification  Binding  Design  Agent  
Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 卷号: 13, 期号: 5, 页码: 1531—1535
Authors:  Ren, J;  Yang, M;  Liu, HC;  Cao, DY;  Chen, DQ;  Li, J;  Tang, L;  He, JH;  Chen, YL;  Geng, MY;  Xiong, B;  Shen, JK
View  |  Adobe PDF(1731Kb)  |  Favorite  |  View/Download:116/41  |  Submit date:2015/12/09
Heat-shock Proteins  3-component Condensation  Discovery  Heat-shock-protein-90  Identification  Pyrazines  Potent  Chaperone  
Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 11, 页码: 2525—2529
Authors:  Ren, J;  Li, J;  Wang, YQ;  Chen, WY;  Shen, AJ;  Liu, HC;  Chen, DQ;  Cao, DY;  Li, YL;  Zhang, NX;  Xu, YC;  Geng, MY;  He, JH;  Xiong, B;  Shen, JK;  mygeng@simm.ac.cn;  hejh@sinap.ac.cn;  bxiong@simm.ac.cn
View  |  Adobe PDF(2396Kb)  |  Favorite  |  View/Download:177/50  |  Submit date:2015/03/13
Shock-protein 90  Drug Discovery  Chaperone  Ligand  Heat-shock-protein-90  Design